29-31 May 2018
San Diego, USA

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Day One
Wednesday, 30th May, 2018

Day Two
Thursday, 31st May, 2018

Conference Day One, Wednesday, 30th May, 2018

08.00
Registration & Breakfast

08.50
Chair’s Opening Remarks

Advancement of Agricultural R&D Through CRISPR & NBTs

09.00
Case Study: CRISPR/Cas: Novel Breeding Technology for Next-Generation of Traits

Synopsis

  • CRISPR/Cas is a key breakthrough in technology that enables development of innovative and sustainable solution for growers and consumers
  • CRISPR/Cas offers tremendous advantage as an advanced breeding tool for applications across traits and crops
  • Next-generation of Waxy corn hybrids are being developed with CRISPR-Cas advanced breeding with a goal to reach the U.S. market by the end of this decade

09.25
Case Study: Primary Targets for New Breeding Technologies: Solving Some Global Problems Where Animal Protein is Needed Most

Synopsis

  • How to get precision bred animals to small holders?
  • How NBTs can solve trade issues related to FMDV?
  • How to apply adaptive variants to ameliorate tropical conditions and climate change?

09.50
Case Study: Marvels of Genome Engineering in the Triticeae Cereals

Synopsis

  • Transition in technology from random to site-directed mutagenesis
  • Range of methods available for genome engineering and delivery of reagents
  • Applications of plant genome engineering in agriculture

10.15
Speed Networking & Morning Refreshments

Improving the Discovery, targeting & Translation of Traits Using CRISPR & NBTS

11.15
Cibus’ Trait Machine is Accelerating Plant Breeding Using the Rapid Trait Development System (RTDS™) with Benefits for Consumers, Farmers and Processors

Synopsis

  • Over thousands of years, breeders have relied on nature’s diversity for crop improvement
  • Cibus has developed a process called the Rapid Trait Development System (RTDS) that combines advanced cell culture and a range of precision breeding methods to accelerate plant breeding by precisely specifying beneficial typographical changes in crop genomes much like a word processor on your computer
  • What used to be a random process taking many years can now be accomplished in months with outcomes indistinguishable from those that can occur in nature

11.45
Case Study: Comprehensive Characterization of On- and Off-target Effects of CRISPR-Cas9 Gene Editing

Synopsis

  • Sequence context drives differences in DNA repair outcomes
  • Biochemical methods can establish the landscape of possible off-target loci
  • Numerous means of biasing editing towards only desired outcomes are available

 

12.10
Computationally-Guided Microbial Remodeling: Flipping the Switch for Better Nutrient Availability and Uptake by Crops

Synopsis

  • Deep understanding of the crop microbiome and microbial physiology to enable microbes to fix and supply more nitrogen to crops
  • Delivery of microbes as seed treatment or in-furrow at the time of planting
  • Meeting needs of farmers, while decreasing inputs and reducing environmental impact

 

 

12.40
Case Study: A Data-Driven Approach to CRISPR Design For Reduced Off-Target Activity in Plant Genome Editing

  • Kan Wang Professor , Iowa State University

Synopsis

  • The importance of CRISPR reagents design for targeted mutagenesis
  • Survey of off-target activities using both biased and un-biased off-target analyses
  • Comparison of different CRISPR/Cas9 and Cpf1 in maize targeted mutagenesis

 

13.05
Panel Discussions: What is the Current and Future Directions of CRISPR & NBTs in Agriculture?

Synopsis

  • What are the major challenges in deployment of genome editing technology in Ag applications?
  • How to optimize our technology and efforts in developing non-transgenic CRISPR/NBTs based products?
  • What are the next technical advancements/replacements of CRISPR & NBTs?

 

Towards New Opportunities in Agriculture: The Era of CRISPR & NBTs

13.45
Networking Lunch

14.45
Case Study: Novel Technology for Generation and Deployment of Genome Edited Variants Across Wide Germplasm Background

Synopsis

  • Genome editing has potential for faster seed product development and commercialization
  • There is lack of efficient way to generate genome edited gene variants in different elite varieties for  field trait performance testing
  • A novel approach is developed to enable genotype-independent generation for evaluation and deployment of edited traits across wide genetic background

 

15.10
Case Study: New Breeding Technologies in Animal Agriculture to Solve Problems in Productivity, Welfare and Sustainability

Synopsis

  • Understanding of fundamental biology to select elite, native traits
  • Use of state-of-the art new breeding technologies to accelerate genetic improvements in livestock (technical capabilities and methods; demonstration of no off-target effects); developing novel traits to solve problems that can’t be addressed through traditional breeding and current genetic stocks (selecting for and accelerating animal health and welfare traits)
  • How NBTs will benefit producers and consumers and change the agricultural industry by growing market size and profitably while producing societal and environmental benefits

 

15.35
Case Study: Designed Variation for Precise Breeding

  • Hanne Volpin Deputy CEO and Head R&D, Danziger Innovations

Synopsis

  • CRISPR based genome editing is relevant for the breeding of all crops, even minor crops
  • The “transformation bottleneck” can be overcome by in planta delivery of the genome editing reagents
  • Regulatory constraints can overcome by transient expression of the genome editing reagents

 

16.00
Case Study: Leveraging biology for National Security

  • Blake Bextine Program Manager, Biological Technologies Office, DARPA

Synopsis

  • Molecular tools to can ensure stability of the global food supply
  • DARPA funds projects at the early innovation stage
  • Once de-risked, industry partners are needed to get newly developed technology to the marketplace

 

16.25
Afternoon Refreshments & Poster Session

CRISPR & NBTs AgBio Breakout Roundtables

16.55
Round Table Discussions:

Synopsis

  1. What are the untapped potentials of CRISPR & NBTs?
  2. How to effectively transit CRISPR & NBTs research to application?
  3. How to precisely predict, monitor and analyze off-target effects of genome editing?
  4. How to gain and maintain consumer trust on genome edited products?

 

17.30
Chair’s Closing Remarks & End of Day One